New class of antibodies may protect against AIDS

A new study has zeroed in on a new defence against HIV-1, the virus that causes AIDS.

The team of researchers at Texas Biomedical Research Institute used an animal model, to show for the first time that an antibody called Immunoglobulin M (IgM) was effective in preventing infection after mucosal AIDS virus exposure.

Scientists first treated the animals with a man-made version of IgM, which is naturally produced by plasma cells located under the epithelium (the surface lining of body cavities). Half an hour later, the same animals were exposed to SHIV (simian-human immunodeficiency virus). Four out of the six animals treated this way were fully protected against the virus. The animals were monitored for 82 days.

“IgM has a high affinity for its antigens and grabs them very quickly and does not let go. Our study reveals for the first time the protective potential of mucosal anti-HIV-1 IgM. IgM has a five-times higher ability to bind to virus particles compared to the standard antibody form called IgG. It basically opens up a new area of research. IgM can do more than it has been given credit,” explained DR. Ruth Ruprecht, a researcher.

ARTICLE SOURCE :- BS

People with HIV infection twice at risk of heart disease

According to a global study, HIV infection doubles the risk of heart disease.

Analysis of global figures reveals that HIV-associated cardiovascular disease has more than tripled in the past 20 years as more people are living longer with the virus.

The greatest impact is in sub-Saharan Africa and Asia Pacific regions, with Swaziland, Botswana and Lesotho particularly affected.

Researchers say the findings will help to target treatments to people facing the greatest risk, helping to maximise resources in countries with limited healthcare funding.

An international team of experts, led by the University of Edinburgh, reviewed studies from 153 countries to determine the rate of heart disease in people living with HIV.

They also calculated the number of years lost as a result of death or ill-health in each country to measure the disease’s global impact – or so-called health burden.

The research, which included studies with almost 800,000 people, found the risk of cardiovascular disease among people living with HIV was double the rate among uninfected people.

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More than two-thirds of the burden of HIV-associated heart disease was found in sub-Saharan Africa and Asia Pacific regions, the study found.

In some parts of the world, HIV ranks alongside better-known risk factors – such as diet and lifestyle – as a major cause of heart disease.

There are more than 35 million people infected with HIV worldwide, a figure that is steadily increasing. Those infected are now more likely to die from chronic diseases, such as cancer or cardiovascular disease, because life-saving medications can keep the virus in check.

The link between HIV and heart disease is poorly understood. Scientists think the virus may cause inflammation of blood vessels, which puts pressure on the cardiovascular system.

The virus is also thought to raise fat levels in the blood and affect the body’s ability to regulate sugar levels, which may also contribute to heart disease.

Dr Anoop Shah, Clinical Lecturer in Cardiology at the University of Edinburgh, said, “This study has important implications when planning cardiovascular preventative policies in low resource countries where the burden of HIV remains high and that of cardiovascular disease is growing.”

The findings have been reported in Circulation.(Article Sporce : BS)